Have you noticed that the workouts you used to do to keep you lean and strong are not working the way you used to? Are you a woman in her early 40s? Well, we might know what is happening.
Perimenopause brings a fog of symptoms, which includes hot flashes, disrupted sleep, mood swings and a metabolism that suddenly feels stubborn. One of the quieter ones is based on the efficiency of your muscles to use the protein you eat. We call that anabolic resistance.

What is anabolic resistance?
Anabolic resistance happens when your muscles start to become less responsive to the dietary protein and resistance exercises, especially in skeletal muscle. This basically means that the diet and workout plans you use to follow to build and maintain muscle may not result in your 40s and 50s.
Well, muscle is a metabolically active tissue, meaning it burns calories even at rest. As muscle mass declines, making weight management progressively harder. Less muscle means a slower metabolism, which helps explain why so many women feel like their body is fighting back during this transition.

Is the RDA for protein too low?
The current Recommended Dietary Allowance (RDA) for protein is 0.8 grams per kilogram of body weight and it was designed ages ago to prevent outright deficiency in the general population.
Dr. Stuart Phillips, Professor of Kinesiology and Canada Research Chair in Skeletal Muscle Health at McMaster University states that the RDA for protein is simply too low for anyone trying to preserve muscle mass and strength as they age.
His research points toward a more useful target for women during perimenopause which is 1.2-1.6 grams of protein per kilogram of body weight daily. This means that a woman weighing around 154lb, needs to consume roughly 84-112 grams a day, which is noticeably more than the RDA and enough to actually counter the muscle’s growing resistance to the anabolic signal protein provides.

Menopause, Muscle and the Nuances
It is tempting to blame all of this to estrogen loss, but recent work co-authored with Phillips takes a more careful look. In a 2026 commentary published in the Journal of Cachexia, Sarcopenia and Muscle, Phillips responds by noting that for years menopause has been framed as a musculoskeletal “breaking point” that inevitably triggers rapid skeletal muscle loss.
According to this work, menopause accelerates an aging process that was already underway. That distinction matters practically because it means that the muscle loss women experience in their 40s and 50s isn’t an unstoppable hormonal cliff that responds to the same tools that build muscle at any age: adequate protein, spread correctly across the day, paired with resistance training.

When you eat protein matters as much as how much you eat it
Phillip’s research group has argued for years that it is well accepted that daily protein intake is important for limiting age-related declines in muscle, strength and function.
This means that eating 30 grams of protein at breakfast, lunch and dinner is far more effective than eating a light breakfast and loading most of the protein into one big meal. Eating protein-rich meals throughout the day, especially at breakfast, helps counteract anabolic resistance.

The Help of Resistance Exercise
Phillips has spent decades studying the relationship between protein and exercise and he’s consistently clear that neither works particularly well alone. He emphasizes that having sufficient muscle mass markedly reduces the risk of dying prematurely and actively challenging those muscles through regular physical activity and exercise may extend a person’s life by several years.
Dietary protein gives your muscles the raw material to rebuild and resistance training gives them the reason to. Without mechanical stimulus, even a calculated protein intake has limited impact on strength or muscle mass. The should go hand in hand instead of being treated as separate boxes to check.

Bringing it Together
The practical formula is:
- 1.2-1.6 g/kg of protein;
- 25-30 grams of protein every meal, prioritizing breakfast;
- Consistent resistance training.
.png)
Having the right support matters
This turns out to be genuinely difficult when applied to a real busy life. Figuring out your actual protein target and restructuring meals you’ve eaten for years and building or adjusting a strength training routine around new priorities is a lot to work out alone, especially during that crazy hormonal phase.
Having a coach who understands the physiology behind this stage tends to make the difference between good intentions and actual results. At Papayya, our trainers hold the most varied degrees, from Physiology, Physical Activity or Health so they can help you build both the meal guidance and the resistance training program around the specifics of where each client is and adjusting as those need to shift.

Bottom Line
You don’t need to lose muscle just because you’re in perimenopause. As Dr. Phillips states that the RDA most of us were taught is outdated for this stage of life and, by eating enough protein at the right times and pairing it consistently with resistance training. If you get those pieces right, and you give your body exactly what it needs to hold onto strength through this transition.
.png)
.webp)
